The Ursinus Weekly, November 6, 1961

Juniors elect Ruby editors; O\u27Donnell, Wurster named • Fashions and fabrics constitute WSGA\u27s Design for Living show • Ursinus\u27 Minnich representative at fitness meeting • Twelve men sign fraternity bids • PSEA schedules Eugene Bertin for speech tomorrow • Forum features Senator Clark Wednesday night • Duryea girls\u27 display Homecoming\u27s finest • Sandy Holl chosen Fall queen; Bears win Homecoming tilt • U.C. Newman Club to hear Pottstown\u27s Father Heim • Editorial: Dropped column; Extra edition • Ferguson, Wirth chosen \u2765 MSGA representatives • Katharine Gibbs School offers two national grants • Bloom on the Gordon-Davis towel • Ursinus in the past • Student concert presents Ormandy • French villages reward tourists with quaint charm, lovely scenes • Booters tie Fords in overtime, 2-2; Alumni loses, 5-2 • Gridders roll over Haverford, 22-6; Quinn passes for two touchdowns • Beaver beaten, 3-1 by hockey girls • Senior fullback Gary Leach wins Walker trophy for fine play Saturday • Consulate posts offered by U.S. State Department • Few local contests in general election Nov. 7 • Dr. R. L. Shinn speaks on Christian faith • Remig names Mrs. Bosler as janitorial coordinator • Chief McClure reports on October police work • Pre-meds attend Hahnemann talks; Club also hears pathology professorhttps://digitalcommons.ursinus.edu/weekly/1303/thumbnail.jp

The Ursinus Weekly, November 6, 1961

Juniors elect Ruby editors; O\u27Donnell, Wurster named • Fashions and fabrics constitute WSGA\u27s Design for Living show • Ursinus\u27 Minnich representative at fitness meeting • Twelve men sign fraternity bids • PSEA schedules Eugene Bertin for speech tomorrow • Forum features Senator Clark Wednesday night • Duryea girls\u27 display Homecoming\u27s finest • Sandy Holl chosen Fall queen; Bears win Homecoming tilt • U.C. Newman Club to hear Pottstown\u27s Father Heim • Editorial: Dropped column; Extra edition • Ferguson, Wirth chosen \u2765 MSGA representatives • Katharine Gibbs School offers two national grants • Bloom on the Gordon-Davis towel • Ursinus in the past • Student concert presents Ormandy • French villages reward tourists with quaint charm, lovely scenes • Booters tie Fords in overtime, 2-2; Alumni loses, 5-2 • Gridders roll over Haverford, 22-6; Quinn passes for two touchdowns • Beaver beaten, 3-1 by hockey girls • Senior fullback Gary Leach wins Walker trophy for fine play Saturday • Consulate posts offered by U.S. State Department • Few local contests in general election Nov. 7 • Dr. R. L. Shinn speaks on Christian faith • Remig names Mrs. Bosler as janitorial coordinator • Chief McClure reports on October police work • Pre-meds attend Hahnemann talks; Club also hears pathology professorhttps://digitalcommons.ursinus.edu/weekly/1303/thumbnail.jp

The Lantern Vol. 29, No. 1, December 1961

• King Fitzgerald\u27s Court • Deliberate Beyond Conception • Jean • The Dumb Superman • Epilogue to Death • Afternoon in August • Eichmann • A Nose Thumbed • Observation • The Forgetful Evening • Truditur Dies Die • The Deserted Pier • Thoughts on Love • Laughter • A Waste? • Villanelle: Interlude • Lines on a Rhetorical Question • Villanellehttps://digitalcommons.ursinus.edu/lantern/1081/thumbnail.jp

The Lantern Vol. 32, No. 1, January 1965

• The Wise Man • Of Men and Lobsters • Deliberate-Beyond Conception • Villanelle • Villanelle: Interlude • Rune Green Stones • Redemption • John Ten • Torch Ends • The General and the Birdnest • Not Quite Free • Hymn to the Morning • Walking Togetherhttps://digitalcommons.ursinus.edu/lantern/1087/thumbnail.jp

Changes in skeletal muscle and tendon structure and function following genetic inactivation of myostatin in rats

Myostatin is a negative regulator of skeletal muscle and tendon mass. Myostatin deficiency has been well studied in mice, but limited data are available on how myostatin regulates the structure and function of muscles and tendons of larger animals. We hypothesized that, in comparison to wild‐type (MSTN+/+) rats, rats in which zinc finger nucleases were used to genetically inactivate myostatin (MSTNΔ/Δ) would exhibit an increase in muscle mass and total force production, a reduction in specific force, an accumulation of type II fibres and a decrease and stiffening of connective tissue. Overall, the muscle and tendon phenotype of myostatin‐deficient rats was markedly different from that of myostatin‐deficient mice, which have impaired contractility and pathological changes to fibres and their extracellular matrix. Extensor digitorum longus and soleus muscles of MSTNΔ/Δ rats demonstrated 20–33% increases in mass, 35–45% increases in fibre number, 20–57% increases in isometric force and no differences in specific force. The insulin‐like growth factor‐1 pathway was activated to a greater extent in MSTNΔ/Δ muscles, but no substantial differences in atrophy‐related genes were observed. Tendons of MSTNΔ/Δ rats had a 20% reduction in peak strain, with no differences in mass, peak stress or stiffness. The general morphology and gene expression patterns were similar between tendons of both genotypes. This large rodent model of myostatin deficiency did not have the negative consequences to muscle fibres and extracellular matrix observed in mouse models, and suggests that the greatest impact of myostatin in the regulation of muscle mass may not be to induce atrophy directly, but rather to block hypertrophy signalling.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111244/1/tjp6572.pd

The Ursinus Weekly, January 15, 1962

Shadowy figure of Ursinus\u27 past publishes volume of 66 poems • Dr. Snyder, Forum speaker, outlines seven strong forces in Africa today • Spontaneous fun object of new social committee • Prof casts critical eye over Lantern; Discovers sound creative instincts • Bursting water pipe sends Alumni Office to 620 Main • Student teachers\u27 light-hearted talk explains what\u27s not in the Ed. book • Best-dressed co-ed sought by Weekly • Shares of the pecuniary pie • Pre-medders hear about corneal transplant work • Editorial: Appeal of wrestling • Ursinus in the past • Letters to the editor • Obituary for a timid intellectual • Dryfoos sets two Ursinus cage marks; Dean ties record with quick pin • Pair of heartbreaking losses catch grapplers last week • Basketball begins • Frymen flounder; Lose to PMC, 92-80; Drop thriller to Swarthmore, 89 to 85 • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1309/thumbnail.jp

The Lantern Vol. 27, No. 3, Fall 1960

• Thoughts in DaVinici\u27s Coffeehouse • Kinesiology Class • No One is Named Alistair • The Beat Generation • The Super Highway Blues • Panic and the Mountain Peak • The Lake • Later • Ares • The Light • The Room • Thoughts After Three-Thirty • Critique • There • Organized Religion - Pro • Organized Religion - Con • Longing • Apologies to Francois Villon • The Fortune Teller • At Twilight • The Ledge • Waiting at Evening for the Sky to Fall • In Memory of a Friend • The Gentleman • Consumption • Post-Panegyric • The Everglades • Awareness • The Art of Two-Timing • Meditations of an Egyptologist • Sonnet to Mao Tse-Tung • A Strange Affair • With Us Tonight • The Form in Fronthttps://digitalcommons.ursinus.edu/lantern/1078/thumbnail.jp

Genetic basis of the very short life cycle of ‘Apogee’ wheat

Background: ‘Apogee’ has a very short life cycle among wheat cultivars (flowering 25 days after planting under a long day and without vernalization), and it is a unique genetic material that can be used to accelerate cycling breeding lines. However, little is known about the genetic basis of the super-short life of Apogee wheat. Results: In this study, Apogee was crossed with a strong winter wheat cultivar ‘Overland’, and 858 F2 plants were generated and tested in a greenhouse under constant warm temperature and long days. Apogee wheat was found to have the early alleles for four flowering time genes, which were ranked in the order of vrn-A1 \u3e VRN-B1 \u3e vrn- D3 \u3e PPD-D1 according to their effect intensity. All these Apogee alleles for early flowering showed complete or partial dominance effects in the F2 population. Surprisingly, Apogee was found to have the same alleles at vrn-A1a and vrn-D3a for early flowering as observed in winter wheat cultivar ‘Jagger.’ It was also found that the vrn-A1a gene was epistatic to VRN-B1 and vrn-D3. The dominant vrn-D3a alone was not sufficient to cause the transition from vegetative to reproductive development in winter plants without vernalization but was able to accelerate flowering in those plants that carry the vrn-A1a or Vrn-B1 alleles. The genetic effects of the vernalization and photoperiod genes were validated in Apogee x Overland F3 populations. Conclusion: VRN-A1, VRN-B1, VRN-D3, and PPD-D1 are the major genes that enabled Apogee to produce the very short life cycle. This study greatly advanced the molecular understanding of the multiple flowering genes under different genetic backgrounds and provided useful molecular tools that can be used to accelerate winter wheat breeding schemes

Behavioural Risk Factors in Mid-Life Associated with Successful Ageing, Disability, Dementia and Frailty in Later Life: A Rapid Systematic Review.

BACKGROUND: Smoking, alcohol consumption, poor diet and low levels of physical activity significantly contribute to the burden of illness in developed countries. Whilst the links between specific and multiple risk behaviours and individual chronic conditions are well documented, the impact of these behaviours in mid-life across a range of later life outcomes has yet to be comprehensively assessed. This review aimed to provide an overview of behavioural risk factors in mid-life that are associated with successful ageing and the primary prevention or delay of disability, dementia, frailty and non-communicable chronic conditions. METHODS: A literature search was conducted to identify cohort studies published in English since 2000 up to Dec 2014. Multivariate analyses and a minimum follow-up of five years were required for inclusion. Two reviewers screened titles, abstracts and papers independently. Studies were assessed for quality. Evidence was synthesised by mid-life behavioural risk for a range of late life outcomes. FINDINGS: This search located 10,338 individual references, of which 164 are included in this review. Follow-up data ranged from five years to 36 years. Outcomes include dementia, frailty, disability and cardiovascular disease. There is consistent evidence of beneficial associations between mid-life physical activity, healthy ageing and disease outcomes. Across all populations studied there is consistent evidence that mid-life smoking has a detrimental effect on health. Evidence specific to alcohol consumption was mixed. Limited, but supportive, evidence was available relating specifically to mid-life diet, leisure and social activities or health inequalities. CONCLUSIONS: There is consistent evidence of associations between mid-life behaviours and a range of late life outcomes. The promotion of physical activity, healthy diet and smoking cessation in all mid-life populations should be encouraged for successful ageing and the prevention of disability and chronic disease.This work was funded by the National Institute for Health and Care Excellence (NICE), invitation to tender reference DDER 42013, and supported by the National Institute for Health Research School for Public Health Research. The scope of the work was defined by NICE and the protocol was agreed with NICE prior to the start of work. The funders had no role in data analysis, preparation of the manuscript or decision to publish.This is the final version of the article. It first appeared from PLOS via http://dx.doi.org/10.1371/journal.pone.014440

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe